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[67] [68] Epidemiology [edit] PA is estimated to affect 0.1% of the general population and 1.9% of those over 60, accounting for 2050% of B 12 deficiency in adults

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Homocysteine-lowering therapy may have some cardiovascular benefits following coronary interventions (11) , but does not appear to lower risk of further cardiovascular events including stroke (12) (13) (14)

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It is therefore used less and less today and has sometimes been heavily criticised (19)